Luuk de Jong scored two first-half goals as Sevilla cruised to 3-0 win over Valencia on Wednesday, reaching the quarter-finals of the Copa del Rey for the second time in three seasons.
Ivan Rakitic also scored in the first half for Sevilla, which also made it to the last eight in 2019.
The five-time Copa champion will be trying to reach the semi-finals for the first time since 2013.
Valencia won its eighth Copa title in 2019 and reached the quarter-finals last season, before losing to Granada.
De Jong scored in the 20th and 33rd minutes at the Ramon Sanchez-Pizjuan Stadium, and Rakitic added the third in the 38th with a neat lob over Valencia goalkeeper Jaume Domenech from inside the area.
Every Sevilla player touched the ball in the build-up of the second goal by De Jong.
The bad news for Sevilla was that captain Jesus Navas had to be replaced because of an apparent muscle injury in the 65th minute.
Sevilla sits fourth in the Spanish league standings.
Valencia, not far from the relegation zone in the league, played without some of its regular starters.